产品货号：
Z23211
中文名称：
PAK2抗体
英文名称：
Anti-PAK2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PAK2 Antibody |
| 指标别名 | PAK2;C-t-PAK2;PAK-2p34;PAK-2p27;p58;PAK-2;S6/H4 kinase;PAK65;Gamma-PAK |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | PAK2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-PAK2 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PAK2.The immunogen is located within amino acids 440-490 of PAK2. |
| 计算分子量 | 58kDa |
| 成分 | PAK2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | PAK2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac.They are divided into two groups,the first of which include PAK1,2 and 3,and can be activated by Cdc42/Rac binding.Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding.The group 1 PAKs are known to be involved in cellular processes such as gene transcription,apoptosis,and cell morphology and motility.Much less is known about the second group,which includes PAK4,5 and 6,and are not activated by Cdc42/Rac binding.Of the six PAK proteins,only PAK2 is ubiquitously expressed and cleaved by caspase-3.This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment.Recent experiments have shown that following cleavage,the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway,but without compromising mitochondrial integrity. |
| Uniprot ID | Q13177 |
| 基因名全称 | P21 protein (Cdc42/Rac)-activated kinase 2 |
| 蛋白名全称 | P21 protein (Cdc42/Rac)-activated kinase 2 |
| 推荐稀释比 | WB:0.5～1μg/mL;IHC:10μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human,mouse and rat samples;Immunohistochemistry and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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